macmillandictionary.com/dict … rreparable
irreparable harm or damage is extremely bad and cannot be repaired or improved

  • The disease does irreparable damage to the nervous system.

irreparable damage, harm etc is so bad that it can never be repaired or made better:

  • Extensive mining will cause irreparable damage to the area.

oxfordadvancedlearnersdictio … rreparable
too bad or too serious to repair or put right

  • to cause irreparable damage/harm to your health
  • Her death is an irreparable loss.