My sister Mary is clever vs My sister, Mary, is clever

My sister, Mary, is clever.
My sister Mary is clever.

Is there any difference between the sentences?

Thanks

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This could mean that you are talking to Mary and Mary is not your sister.

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They have a slightly different meaning because of the context.

My sister, Mary, is clever. - I have one sister and her name is Mary.
My sister Mary is clever. - I may have other sisters, but here I’m talking about Mary. My other sisters Edith and Sybil may not be clever.

And as @Torsten says, you could be talking to someone named Mary.

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This could mean that you are talking to Mary and Mary is not your sister.

Can it be phrased as “Mary, my sister is clever.”?

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Yes, certainly.

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My sister, Mary, is clever. - To avoid mistaking the name for an address, the sentence may be rephrased and written as a non-defining phrase or clause ‘in apposition’ as below:
Mary, (who is) my sister, is clever.

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