If there is anything in this world about which I know positively nothing, it is …
If there is anything in this world about what I know positively nothing, it is …
If there is anything in this world about which I know positively nothing, it is …
If there is anything in this world about what I know positively nothing, it is …
I think there are both awkward and difficult to understand.
Here is my suggestion:
If there is anything I definitely know nothing about, it is…
However, even this sentence probably isn’t quite true because if you know that something exists you already know something about it.
I agree, but I think there’s no other way to make this clear.