What, do you think, should I do first?

  1. What, do you think, should I do first?
  2. What should I do, do you think?
    Are the above sentences acceptable?
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Best to combine both as - What do you think I should do (first)?

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No.

  1. What do you think I should do first? (This corrected form is acceptable as Alan has suggested)
  2. What should I do, do you think? (This sentence doesn’t make good sense; it also has two questions within itself, which is not grammatical)
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